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Online learning is a technique of instruction that does not include face-to-face interaction between teachers and students that was employed during the epidemic. This learning method is a solution to the limitations of learning activities during the current Covid-19 pandemic. To support online learning and assist the learning process, there are currently many applications that provide video conferencing facilities so that educators and students can still communicate. The Zoom application is one of them, many schools use this application because this application has features that can help the teaching and learning process. This study aims to find out in-depth how the adoption of the use of the Zoom application as a learning tool in a private school to increase neuro-cognitive students. This study uses a qualitative method. The population is all students in a private school with a sample of 18 students who filled out the survey. Data collection techniques using the questionnaire method. Based on the data analysis that has been carried out, it was concluded that 83.4% of respondents admitted that adopting the Zoom application as a learning medium in their schools was effective to increase neuro-cognitive as well as student responses while using the Zoom application as an online learning medium were very enjoyable. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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Objective: Coronavirus disease causes a wide spectrum of clinical picture in pregnant women. There are still a few studies concerning laboratory parameters to differentiate the severity of coronavirus disease-19 in pregnant patients. This article aims to identify the cut-off on laboratory parameters between pregnant women with asymptomatic/mild/moderate and severe/critical coronavirus disease-19 illness. Methods: All coronavirus disease-19 pregnant women coming to Dr. Cipto Mangunkusumo hospital between January and August 2021 were recruited into this cross-sectional study. All data extracted from medical records were classified into demographic characteristics and laboratory parameters. We defined demographic characteristics as age, parity, systolic, and diastolic blood pressure, heart rate, temperature, respiratory rate, and oxygen saturation. Laboratory parameters measured in this study consisted of complete blood count, renal function test including urea, creatinine, liver function test including aspartate transferase, alanine transferase, infection marker test including procalcitonin, C-reactive protein, interleukin-6, cycle threshold values, ferritin, coagulation test including d-dimer, fibrinogen, random blood glucose, albumin, electrolytes. Data analysis was performed using SPSS statistics. Results: There were 159 cases assessed in this study consisting of 130 (81.8%) patients with asymptomatic/mild/moderate illness and 29 (18.2%) patients with severe/critical illness of coronavirus disease-19. Of 28 laboratory parameters, 12 of them were significant statistically; thus, it resulted to make a cut-off using receiver operating characteristic curve and show relative risk, and 95% confidence interval. In multivariate analysis that aspartate transferase, D-dimer, and albumin were laboratory parameters impacted to the severity of coronavirus disease-19 in pregnant women. The area under receiver operating characteristic curve was 0.834 (95% CI 0.736-0.932). Conclusion: Of all laboratory parameters, urea, aspartate transferase, alanine transferase, procalcitonin, C-reactive protein, lactate dehydrogenase (LDH), ferritin, D-dimer, random blood glucose, cycle threshold values, albumin, and chloride differs between asymptomatic/mild/moderate, and severe/critical illness coronavirus disease-19 in pregnant women; aspartate transferase, D-dimer, and albumin were laboratory parameters impacted the most to the severity of coronavirus disease-19 in pregnant women.
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Cardiac arrest in pregnancy is very rare. Various methods have been proposed to return spontaneous circulation and prevent mortality, such as Perimortem Caesarean Section (PMCS). Since 2019, the COVID-19 pandemic has added to the difficulty in decision making and performing PMCS. Infection prevention being a priority due to the rapid spreading of the virus could cause hesitation upon initiating an emergency procedure, especially PMCS. We have reviewed the issues impacting on basic and advanced life support in adults with suspected or confirmed COVID-19.
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Analysis and design of e-office application on ministry health of Republic of Indonesia based on microservice architecture. The system is converting from monolithic architecture into microservice architecture by using domain driven design framework to breaking the domain business of the system. Microservice architecture is an important part to agile, resilience, and high-availability. By improvement the feature and the high intention to use to the system by regulation of e-government of Republic of Indonesia at Ministry bureaucracy. By using the Microservice Architecture will improve the productivity of employee, increase the public services, adaptable in current condition of pandemic covid-19 cases in Indonesia. © 2022 Little Lion Scientific
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Corona disease-19 virus (COVID-19) spread and caused a pandemic that affected people all over the world. COVID-19 is also called Severe Acute Respiratory Syndrome-Coronavirus Disease (SARS-CoV). Discussion: COVID-19 is a β-Coronavirus serotype which is a single strain of RNA virus and was an outbreak in 2002 (SARS-CoV) and 2012 (MERS-CoV). COVID-19 has Open Reading Frames (ORFs) consisting of Spikes (S) Envelopes (E) Membranes (M) and Nucleocapsids (N) with S parts being a glycoprotein that can attach to receptors owned by host cells the receptors are CD 26 ACE-2 Ezrin and Cyclophilins with the main receptor being ACE-2 in the lung organs. Process would evoke a host body's immune response consisting of natural and adaptive immune systems involving the Antigen Presenting Cell (APC) system which consists of two namely: Major Histocompatibility Complex (MHC) class I and II. APC could also generate an adaptive immune system consisting of B and T cells. COVID-19 had the ability to survive in B and T cells so that cytokine-chemokine secretion continues to be known as cytokine storms that trigger Acute Respiratory Distress Syndrome (ARDS) and death. Conclusion: The recovery prognosis of COVID-19 depended on the detection of COVID-19 patients because it was related to the severity of ARDS so the earlier it was detected the greater the chance of recovery. Keywords : Corona serotype β virus infection, SARS-MERS, ACE2-CD26, cytokines-chemokines, ARDS
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A thyroid storm (or thyroid crisis) is an emergency in endocrinology. It is a form of complication of hyperthyroidism that can be life-threatening. Inadequate control of hyperthyroidism in pregnancy could develop into thyroid storm, especially in the peripartum period. We present a woman came in the second stage of labour, with thyroid storm, superimposed pre-eclampsia, acute lung oedema and impending respiratory failure. Treatment for thyroid storm, pre-eclampsia protocol and corticosteroid was delivered. The baby was born uneventfully, while the mother was discharged after 5 days of hospitalisation. Delivery is an important precipitant in the development of thyroid storm in uncontrolled hyperthyroidism in pregnancy. Although very rare, it can cause severe consequences. Diagnosis and treatment guidelines for thyroid storm were available and should be done aggressively and immediately. Uncontrolled hyperthyroidism should be prevented by adequate control in thyroid hormone levels, especially before the peripartum period.
Subject(s)
Pre-Eclampsia , Thyroid Crisis , Emergency Service, Hospital , Female , Humans , Labor Stage, Second , Pregnancy , Thyroid Crisis/diagnosis , Thyroid Crisis/drug therapyABSTRACT
World, especially Indonesia, is experiencing pandemic virus infection called Corona Virus Disease-19 (COVID-19) or Severe Acute Respiratory Syndrome Corona Virus-2 (SARS CoV-2). COVID-19 was firstly outbreak in Wuhan City on December 31 2019, having major receptors on Angiotensin Converting Enzyme-2 (ACE-2), especially located on lungs. One of its transmissions due to droplet and bioaerosol transmission,its attachment by the Spike 1 (S1) protein, and the invasion process by Spike 2 (S2). Invasion process stimulates host immunity resulting in excessive cytokines-chemokines production (cytokine storm) that has negative effect on the lungs, Acute Respiraatory Disease Syndrome (ARDS), and death. The New Normal phase is a new habit living with COVID-19 must be applied by community so that it reaches the treshold (Ro and Pc) on Herd Immunity and life postCOVID-19. There is a simple model that describes the components involved in Herd Immunity, namely: susceptible people exposed and recovered from COVID-19. © 2021 UPM Press. All rights reserved.
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More than 90% of deaths are considered to be natural deaths, but there are some cases where the cause is not yet certain. In doubtful cases, an autopsy is required. In the COVID-19 pandemic, forensic experts must wear personal protective equipment to prevent the transmission of the virus or other diseases from corpses for autopsy. In this case report, on May 30th, 2020, a 40-years-old man was taken by his family to the hospital. Based on the doctor's examination, the man was dead when he arrived at the Emergency Room. Doctors found bruises on his cheek and left eyelid. The police conducting the crime scene examination was not sure whether the bruises were due to repeated falls or due to a crime. Therefore, an autopsy was done even in the COVID-19 pandemic to ensure whether the cause of death was natural or unnatural. © 2021 UPM Press. All rights reserved.
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INTRODUCTION: Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infection that causes novel Coronavirus Disease 2019 (COVID-19) has become a major health problem worldwide and been declared a pandemic since March 2020 by WHO. One special population that poses a challenge is pregnant women with COVID-19. There have not been many studies related to COVID-19 in pregnancy. In this study, we present five serial cases of Remdesivir treatment for COVID-19 in pregnant women with moderate to severe symptoms. CASE ILLUSTRATION: We briefly describe five serial cases being treated with Remdesivir therapy during hospitalization. Four cases were delivered by cesarean section, and one was delivered vaginally in gestation week 37. All cases showed a shortened duration of hospitalization, rapid improvement in clinical symptoms, and no adverse events were observed in mothers, fetuses, and neonates. DISCUSSION: Remdesivir, an inhibitor RNA Polymerase, has been used in COVID-19 treatment and is known to shorten recovery time in nonpregnant women. Some studies have shown no adverse effects on Remdesivir for pregnant women. Based on randomized control trial (RCT) during the Ebola epidemic, Remdesivir was safe to use for pregnant women. All cases showed reduced hospitalization time and better clinical outcomes without maternal, fetal, or neonatal adverse events. CONCLUSION: Remdesivir protocol for pregnant women with moderate to severe symptoms of COVID-19 has resulted in better clinical improvement with a shorter recovery period and no adverse effects during the hospitalization period. Further studies and RCT are warranted to evaluate the biosafety and effects of Remdesivir in pregnant women.